MagpieRSS Object
(
[parser] => 0
[current_item] => Array
(
)
[items] => Array
(
[0] => Array
(
[title] => Socioeconomic factors affect response to depression treatment
[link] => https://bestmovies.movs.world/healthandscience/socioeconomic-factors-affect-response-to-depression-treatment/
[dc] => Array
(
[creator] => Tony Grantly
)
[pubdate] => Sat, 16 Apr 2022 06:30:30 +0000
[category] => Health And ScienceaffectdepressionFactorsresponseSocioeconomicTreatment
[guid] => https://bestmovies.movs.world/?p=106913
[description] => Journal Reference: Jeffrey A. Mills, Vikram Suresh, Lenisa Chang, Taryn Mayes, Paul E. Croarkin, Madhukar H. Trivedi, Jeffrey R. Strawn. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatric Services, 2022; DOI: 10.1176/appi.ps.202100559 Led by Jeffrey Mills, PhD, and Jeffrey Strawn, MD, the UC cross-college collaborative research was recently published in the ... Read more
[content] => Array
(
[encoded] =>
Journal Reference:
Jeffrey A. Mills, Vikram Suresh, Lenisa Chang, Taryn Mayes, Paul E. Croarkin, Madhukar H. Trivedi, Jeffrey R. Strawn. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatric Services, 2022; DOI: 10.1176/appi.ps.202100559
Led by Jeffrey Mills, PhD, and Jeffrey Strawn, MD, the UC cross-college collaborative research was recently published in the journal Psychiatric Services.
Strawn, professor in the Department of Psychiatry and Behavioral Neuroscience in UC?s College of Medicine and a UC Health adolescent psychiatrist, said that previous research has concluded that people seeking treatment for depression with lower income and less education have worse outcomes because of a lack of access to quality health care, but it is hard to isolate socioeconomic factors as they are often intertwined.
The research team analyzed data from a very large clinical trial known as CO-MED that enrolled 665 patients seeking treatment for depression. In the randomized trial, all patients had the same access to treatment without differences due to health insurance or income.
Study results
After controlling for sex, age and treatment type following 12 weeks of antidepressant medication treatment in the study, the team?s analysis found patients who were non-white improved 11.3% less compared to white patients. Those who were unemployed saw 6.6% less improvement compared to employed patients. Compared to patients in the 75th percentile of income distribution, patients having income at the 25th percentile reduced improvement by 4.8%.
Strawn noted the findings are still preliminary, but he was particularly interested to find that patients without a college degree had 9.6% less improvement compared to college graduates.
?We think about these things in terms of access, we think about them in terms of income inequality, and I realize that education does track with those, but just having a college degree while controlling for all of these other factors still had a significant impact,? said Strawn.
The researchers also examined the effect of the combination of socioeconomic factors, since the individual factors are often correlated, Mills said. Patients who were non-white, unemployed with no degree and had income in the 25th percentile had 26% less improvement compared to patients who were white, employed with a college degree and had income in the 75th percentile.
Mills said that the findings do not negate the fact that a lack of access makes an impact on treatment outcomes, but it does show the importance of including a patients? home environment when analyzing the effectiveness of treatment.
?If you?re going home to a wealthy neighborhood with highly educated parents or spouse, then you?re arguably in a much better environment for the treatment to be effective than if you?re going to a poor neighborhood with other problems,? said Mills, professor of economics in UC?s Carl H. Lindner College of Business.
Strawn said other research suggests patients in resource-poor environments may be affected by greater chronic variable stress, meaning high stress in a pattern that is intermittent and difficult to predict. Other studies suggest chronic variable stress has a worse effect on patients than chronic sustained stress that is more steady, he said.
?So this is, ?I was able to pay my rent this month, but I?m not sure that I will be able to next month. And I have a job right now, but I don?t know that I will next month,’? Strawn said. ?So it?s just the impact of all those things as well as maybe having relatives or kids who have fewer educational resources or other job-related stress, or potentially other health problems, and you?re still running into those same barriers in terms of access and cost and support there.?
Research application
The study findings have the potential to impact clinical trials by designing studies that pay better attention to socioeconomic variables that may have been previously overlooked, Strawn said.
?When we don?t control for these variables, which we often do not in our clinical trials because of differences in populations, we may miss detecting an effective treatment because its effect is obscured,? Strawn said. ?So it can potentially jeopardize our treatment development by not accounting for these factors.?
Strawn said those treating patients every day can use the knowledge from the study in a more straightforward approach. While removing barriers of access to treatment is important, he said clinicians must also acknowledge that a patient?s socioeconomic environment may be affecting their ability to get better with treatment when measuring progress and crafting future treatment plans.
Mills said the research also has important implications when crafting and implementing economic policy, such as the recently passed infrastructure bill or ongoing discussions on the minimum wage. The impact of a policy on an individual?s socioeconomic environment, and subsequently their mental health, is not typically considered, he said.
?Someone employed at a higher wage has a chance to improve their socioeconomic status and environment, and so they?re definitely less likely to get mental health problems,? he said. ?If people with higher socioeconomic status do get mental health problems, what we?re showing is they?re more likely to improve if they get treatment.?
Team science
In the past, two researchers with different specialties in different colleges within a university may have never worked together on research like this, but the collaboration shows the benefit of what is called team science, a transdisciplinary approach to research.
Strawn explained that traditional multidisciplinary research often looks like a psychiatrist, a neurologist and a psychologist all within the College of Medicine working together on a project. While that has its place, team science works across disciplines and involves completely separate sets of expertise, concepts and approaches.
?We think of multidisciplinary as being kind of the fruit salad where you have your grapes and your bananas, but everything is still distinct,? Strawn said. ?And then you have your transdisciplinary, where things are really blended and it?s difficult to tell whose contributions are whose. That?s probably more like the fruit smoothie of disciplinary integration. I think that?s hopefully what we?ve achieved.?
Mills said he has previously seen colleagues expected to closely collaborate who never published a paper together because their skill sets were too similar and they did not need each other to move forward. Alternatively, Mills and Strawn have interest in each other?s field and bring varying, complementary skill sets to the research.
?It?s further than just multidisciplinary, because if I get together with my colleagues, we still have had very similar training. We use the same jargon, we have similar ideas,? Mills said. ?There?s not the same cross pollination in stepping out of your field and thinking about other topics and giving each other ideas and concepts that you may not have thought about.?
Moving forward, the researchers want to continue the research by combining data from other depression trials to produce more powerful results with a larger dataset.
We would love to say thanks to the author of this article for this outstanding content
)
[summary] => Journal Reference: Jeffrey A. Mills, Vikram Suresh, Lenisa Chang, Taryn Mayes, Paul E. Croarkin, Madhukar H. Trivedi, Jeffrey R. Strawn. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatric Services, 2022; DOI: 10.1176/appi.ps.202100559 Led by Jeffrey Mills, PhD, and Jeffrey Strawn, MD, the UC cross-college collaborative research was recently published in the ... Read more
[atom_content] =>
Journal Reference:
Jeffrey A. Mills, Vikram Suresh, Lenisa Chang, Taryn Mayes, Paul E. Croarkin, Madhukar H. Trivedi, Jeffrey R. Strawn. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatric Services, 2022; DOI: 10.1176/appi.ps.202100559
Led by Jeffrey Mills, PhD, and Jeffrey Strawn, MD, the UC cross-college collaborative research was recently published in the journal Psychiatric Services.
Strawn, professor in the Department of Psychiatry and Behavioral Neuroscience in UC?s College of Medicine and a UC Health adolescent psychiatrist, said that previous research has concluded that people seeking treatment for depression with lower income and less education have worse outcomes because of a lack of access to quality health care, but it is hard to isolate socioeconomic factors as they are often intertwined.
The research team analyzed data from a very large clinical trial known as CO-MED that enrolled 665 patients seeking treatment for depression. In the randomized trial, all patients had the same access to treatment without differences due to health insurance or income.
Study results
After controlling for sex, age and treatment type following 12 weeks of antidepressant medication treatment in the study, the team?s analysis found patients who were non-white improved 11.3% less compared to white patients. Those who were unemployed saw 6.6% less improvement compared to employed patients. Compared to patients in the 75th percentile of income distribution, patients having income at the 25th percentile reduced improvement by 4.8%.
Strawn noted the findings are still preliminary, but he was particularly interested to find that patients without a college degree had 9.6% less improvement compared to college graduates.
?We think about these things in terms of access, we think about them in terms of income inequality, and I realize that education does track with those, but just having a college degree while controlling for all of these other factors still had a significant impact,? said Strawn.
The researchers also examined the effect of the combination of socioeconomic factors, since the individual factors are often correlated, Mills said. Patients who were non-white, unemployed with no degree and had income in the 25th percentile had 26% less improvement compared to patients who were white, employed with a college degree and had income in the 75th percentile.
Mills said that the findings do not negate the fact that a lack of access makes an impact on treatment outcomes, but it does show the importance of including a patients? home environment when analyzing the effectiveness of treatment.
?If you?re going home to a wealthy neighborhood with highly educated parents or spouse, then you?re arguably in a much better environment for the treatment to be effective than if you?re going to a poor neighborhood with other problems,? said Mills, professor of economics in UC?s Carl H. Lindner College of Business.
Strawn said other research suggests patients in resource-poor environments may be affected by greater chronic variable stress, meaning high stress in a pattern that is intermittent and difficult to predict. Other studies suggest chronic variable stress has a worse effect on patients than chronic sustained stress that is more steady, he said.
?So this is, ?I was able to pay my rent this month, but I?m not sure that I will be able to next month. And I have a job right now, but I don?t know that I will next month,’? Strawn said. ?So it?s just the impact of all those things as well as maybe having relatives or kids who have fewer educational resources or other job-related stress, or potentially other health problems, and you?re still running into those same barriers in terms of access and cost and support there.?
Research application
The study findings have the potential to impact clinical trials by designing studies that pay better attention to socioeconomic variables that may have been previously overlooked, Strawn said.
?When we don?t control for these variables, which we often do not in our clinical trials because of differences in populations, we may miss detecting an effective treatment because its effect is obscured,? Strawn said. ?So it can potentially jeopardize our treatment development by not accounting for these factors.?
Strawn said those treating patients every day can use the knowledge from the study in a more straightforward approach. While removing barriers of access to treatment is important, he said clinicians must also acknowledge that a patient?s socioeconomic environment may be affecting their ability to get better with treatment when measuring progress and crafting future treatment plans.
Mills said the research also has important implications when crafting and implementing economic policy, such as the recently passed infrastructure bill or ongoing discussions on the minimum wage. The impact of a policy on an individual?s socioeconomic environment, and subsequently their mental health, is not typically considered, he said.
?Someone employed at a higher wage has a chance to improve their socioeconomic status and environment, and so they?re definitely less likely to get mental health problems,? he said. ?If people with higher socioeconomic status do get mental health problems, what we?re showing is they?re more likely to improve if they get treatment.?
Team science
In the past, two researchers with different specialties in different colleges within a university may have never worked together on research like this, but the collaboration shows the benefit of what is called team science, a transdisciplinary approach to research.
Strawn explained that traditional multidisciplinary research often looks like a psychiatrist, a neurologist and a psychologist all within the College of Medicine working together on a project. While that has its place, team science works across disciplines and involves completely separate sets of expertise, concepts and approaches.
?We think of multidisciplinary as being kind of the fruit salad where you have your grapes and your bananas, but everything is still distinct,? Strawn said. ?And then you have your transdisciplinary, where things are really blended and it?s difficult to tell whose contributions are whose. That?s probably more like the fruit smoothie of disciplinary integration. I think that?s hopefully what we?ve achieved.?
Mills said he has previously seen colleagues expected to closely collaborate who never published a paper together because their skill sets were too similar and they did not need each other to move forward. Alternatively, Mills and Strawn have interest in each other?s field and bring varying, complementary skill sets to the research.
?It?s further than just multidisciplinary, because if I get together with my colleagues, we still have had very similar training. We use the same jargon, we have similar ideas,? Mills said. ?There?s not the same cross pollination in stepping out of your field and thinking about other topics and giving each other ideas and concepts that you may not have thought about.?
Moving forward, the researchers want to continue the research by combining data from other depression trials to produce more powerful results with a larger dataset.
We would love to say thanks to the author of this article for this outstanding content
[date_timestamp] => 1650090396
)
[2] => Array
(
[title] => Francesco Bianconi annuncia ?Perduto Insieme a Te?, il nuovo singolo cantato insieme ad un?amata collega
[link] => https://bestmovies.movs.world/music/francesco-bianconi-annuncia-perduto-insieme-a-te-il-nuovo-singolo-cantato-insieme-ad-unamata-collega/
[dc] => Array
(
[creator] => Ann Moon
)
[pubdate] => Sat, 16 Apr 2022 06:16:49 +0000
[category] => MusicannunciaBianconicantatocollegaFrancescoinsiemenuovoPerdutosingolounamata
[guid] => https://bestmovies.movs.world/?p=106901
[description] => Francesco Bianconi Perduto insieme a te è il nuovo singolo con Malika Ayane. Scrive così sui suoi profili social Bianconi: Uscirà il 20 aprile una mia nuova canzone che si chiama ?Perduto insieme a te?. La canto insieme a Malika Ayane, che è meravigliosa e dà come pochi sanno fare il soul a tutto ciò che ... Read more
[content] => Array
(
[encoded] =>
Francesco Bianconi Perduto insieme a te è il nuovo singolo con Malika Ayane.
Scrive così sui suoi profili social Bianconi:
Uscirà il 20 aprile una mia nuova canzone che si chiama ?Perduto insieme a te?. La canto insieme a Malika Ayane, che è meravigliosa e dà come pochi sanno fare il soul a tutto ciò che tocca. Per soul non intendo il genere musicale ma il vento di gioia che certe voci hanno dentro anche quando cantano del buio più nero e della più profonda disperazione. ?Perduto insieme a te? è solo un?altra canzone d?amore: spero che vi piaccia e che vi aiuti un po? a sopportare il peso di questo momento storico orribile.
Francesco Bianconi torna con un brano dal testo aperto al futuro e alla speranza, come lo definisce l?autore: ?una canzone d?amore per questi tempi maledetti di inquietudine e incertezza, che spero possa dare un po? di conforto a chi l?ascolta. In fondo è l?unica cosa che possono fare le canzoni, per il loro potere salvifico e taumaturgico: come le poesie, le canzoni uniscono e possono essere un antidoto contro la sofferenza.? In questo brano per la prima volta Francesco Bianconi collabora con Malika Ayane e a proposito della sua partecipazione alla canzone, l?autore racconta di aver cercato per molto tempo di scrivere o lavorare con lei ?mi piace moltissimo la sua voce, la sua fisicità, il suo modo di porsi nell?interpretazione. Quindi mi sono rivolto a lei quasi automaticamente.
Quando Francesco scriveva già canzoni famose, io avevo appena vent?anni e nessun piano nella vita. Ero rimasta fortemente colpita da come nella sua musica la malinconia fosse portata con leggerezza e naturalezza. Nel tempo, quando ho conosciuto meglio il suo lavoro, mi sono chiesta tante volte come riuscisse a raccontare e cantare tanto bene quello stato d?animo in cui mi trovo spesso ma che non so definire con altrettanta grazia. Poi ci siamo sfiorati mille volte finché non mi ha chiesto di cantarlo insieme e non ho potuto resistere. ?Perduto insieme a te?è una canzone bellissima e spero arrivi a più persone possibile.? racconta Malika.
Francesco Bianconi Perduto insieme a te insieme a Malika Ayane
La parte musicale del brano ? mixato a New York da Sam Evian ? è curata da Amedeo Pace (il produttore, che per il brano suona anche alcune parti di chitarra), da Angelo Trabace al pianoforte, da Simone Pace alla batteria, da Brian Betancourt al basso elettrico, ed Eleanor Norton e Megan Gould agli archi. Il solo nel secondo ritornello è suonato dallo stesso Bianconi, che doppia la Epiphone Riviera con la sua gloriosa baritono Teisco degli anni Sessanta.
A maggio Francesco Bianconi pubblicherà in contemporanea, in Italia e in Francia, un altro singolo dal titolo CIAO, firmato insieme alla compositrice e cantante francese Clio, stella nascente della musica d?autore d?oltralpe. Il brano segna il debutto di Francesco sul mercato discografico francese, da sempre nella sua orbita creativa; CIAO anticipa infatti la pubblicazione di FOREVER in Francia, che per l?occasione l?autore presenterà con un live all?Istituto Italiano di Cultura, in autunno.
Francesco Bianconi Perduto insieme a te
francesco bianconi e la stupefacente band
Francesco Bianconi, accompagnato da La Sua Stupefacente Band, torna al suo primo amore, il live, e nel prossimo mese di maggio sarà in tour nei teatri ? partenza da Fermo il 13 ? il 20 maggio a Firenze al Teatro Puccini e il 21 a Roma all?Auditorium Parco della Musica, per poi toccare le principali città italiane.
Sarà l?occasione per presentare i suoi ultimi lavori in studio, in una summa ideale della sua prolifica produzione, dai progetti più recenti ad incursioni nel recente passato, ma non solo: il cantautore ha infatti pensato questo nuovo tour come ?una storia a parte? dove protagoniste saranno ?elettricità, percussione, tensione e massa sonica? ? anticipa Bianconi ? alternate a momenti più acustici con le canzoni degli ultimi dischi in primo piano, ma anche l?occasione per presentare nuovi brani inediti.
)
[summary] => Francesco Bianconi Perduto insieme a te è il nuovo singolo con Malika Ayane. Scrive così sui suoi profili social Bianconi: Uscirà il 20 aprile una mia nuova canzone che si chiama ?Perduto insieme a te?. La canto insieme a Malika Ayane, che è meravigliosa e dà come pochi sanno fare il soul a tutto ciò che ... Read more
[atom_content] =>
Francesco Bianconi Perduto insieme a te è il nuovo singolo con Malika Ayane.
Scrive così sui suoi profili social Bianconi:
Uscirà il 20 aprile una mia nuova canzone che si chiama ?Perduto insieme a te?. La canto insieme a Malika Ayane, che è meravigliosa e dà come pochi sanno fare il soul a tutto ciò che tocca. Per soul non intendo il genere musicale ma il vento di gioia che certe voci hanno dentro anche quando cantano del buio più nero e della più profonda disperazione. ?Perduto insieme a te? è solo un?altra canzone d?amore: spero che vi piaccia e che vi aiuti un po? a sopportare il peso di questo momento storico orribile.
Francesco Bianconi torna con un brano dal testo aperto al futuro e alla speranza, come lo definisce l?autore: ?una canzone d?amore per questi tempi maledetti di inquietudine e incertezza, che spero possa dare un po? di conforto a chi l?ascolta. In fondo è l?unica cosa che possono fare le canzoni, per il loro potere salvifico e taumaturgico: come le poesie, le canzoni uniscono e possono essere un antidoto contro la sofferenza.? In questo brano per la prima volta Francesco Bianconi collabora con Malika Ayane e a proposito della sua partecipazione alla canzone, l?autore racconta di aver cercato per molto tempo di scrivere o lavorare con lei ?mi piace moltissimo la sua voce, la sua fisicità, il suo modo di porsi nell?interpretazione. Quindi mi sono rivolto a lei quasi automaticamente.
Quando Francesco scriveva già canzoni famose, io avevo appena vent?anni e nessun piano nella vita. Ero rimasta fortemente colpita da come nella sua musica la malinconia fosse portata con leggerezza e naturalezza. Nel tempo, quando ho conosciuto meglio il suo lavoro, mi sono chiesta tante volte come riuscisse a raccontare e cantare tanto bene quello stato d?animo in cui mi trovo spesso ma che non so definire con altrettanta grazia. Poi ci siamo sfiorati mille volte finché non mi ha chiesto di cantarlo insieme e non ho potuto resistere. ?Perduto insieme a te?è una canzone bellissima e spero arrivi a più persone possibile.? racconta Malika.
Francesco Bianconi Perduto insieme a te insieme a Malika Ayane
La parte musicale del brano ? mixato a New York da Sam Evian ? è curata da Amedeo Pace (il produttore, che per il brano suona anche alcune parti di chitarra), da Angelo Trabace al pianoforte, da Simone Pace alla batteria, da Brian Betancourt al basso elettrico, ed Eleanor Norton e Megan Gould agli archi. Il solo nel secondo ritornello è suonato dallo stesso Bianconi, che doppia la Epiphone Riviera con la sua gloriosa baritono Teisco degli anni Sessanta.
A maggio Francesco Bianconi pubblicherà in contemporanea, in Italia e in Francia, un altro singolo dal titolo CIAO, firmato insieme alla compositrice e cantante francese Clio, stella nascente della musica d?autore d?oltralpe. Il brano segna il debutto di Francesco sul mercato discografico francese, da sempre nella sua orbita creativa; CIAO anticipa infatti la pubblicazione di FOREVER in Francia, che per l?occasione l?autore presenterà con un live all?Istituto Italiano di Cultura, in autunno.
Francesco Bianconi Perduto insieme a te
francesco bianconi e la stupefacente band
Francesco Bianconi, accompagnato da La Sua Stupefacente Band, torna al suo primo amore, il live, e nel prossimo mese di maggio sarà in tour nei teatri ? partenza da Fermo il 13 ? il 20 maggio a Firenze al Teatro Puccini e il 21 a Roma all?Auditorium Parco della Musica, per poi toccare le principali città italiane.
Sarà l?occasione per presentare i suoi ultimi lavori in studio, in una summa ideale della sua prolifica produzione, dai progetti più recenti ad incursioni nel recente passato, ma non solo: il cantautore ha infatti pensato questo nuovo tour come ?una storia a parte? dove protagoniste saranno ?elettricità, percussione, tensione e massa sonica? ? anticipa Bianconi ? alternate a momenti più acustici con le canzoni degli ultimi dischi in primo piano, ma anche l?occasione per presentare nuovi brani inediti.
[date_timestamp] => 1650089809
)
[3] => Array
(
[title] => 10 Movies That Are Too Scary To Finish, According To Ranker
[link] => https://bestmovies.movs.world/scream-away/10-movies-that-are-too-scary-to-finish-according-to-ranker/
[dc] => Array
(
[creator] => Harry World
)
[pubdate] => Sat, 16 Apr 2022 05:59:43 +0000
[category] => Scream AwayfinishMoviesRankerScary
[guid] => https://bestmovies.movs.world/?p=106895
[description] => Content Warning: This article contains graphic references and discussions of racism Now that horror auteur Jordan Peele is returning to the big screen with his new film Nope, audiences are guaranteed to get a healthy dose of terror that will send them fleeing from the theater. The horror genre has spooked viewers since the beginning of film history, ... Read more
[content] => Array
(
[encoded] =>
Content Warning: This article contains graphic references and discussions of racism
Now that horror auteur Jordan Peele is returning to the big screen with his new film Nope, audiences are guaranteed to get a healthy dose of terror that will send them fleeing from the theater. The horror genre has spooked viewers since the beginning of film history, but certain movies have found a way to scare as much of their audience as possible.
RELATED: 10 Most Confusing Horror Movies, According To Reddit
Whether its supernatural horror like in The Conjuring, or downright gross films like The Human Centipede 2, some films push viewers to their absolute breaking point. Though there are many classic chillers, users on Ranker took to the site to vote for the films that they were too scared to finish watching.
SCREENRANT VIDEO OF THE DAY
It (1990)
Generally considered one of Stephen King’s best TV adaptations, It attempted to capture one of the author’s densest tomes. Set in the 1960s and 1990s, a group of friends band together to stop a mysterious and deadly being that manifests itself as a clown named Pennywise.
Essentially sparking the “scary clown” phase of horror, King’s story featured a wide variety of interesting characters and freaky scenes. Because so many viewers saw It when they were younger, a lot of the scariest moments have stuck with fans over three decades since the TV movie’s release.
The Green Inferno (2013)
Attempting to recreate the magic of classic grindhouse horror films like Cannibal Holocaust, Eli Roth’s The Green Inferno took its horrors to the jungles of the Amazon. A group of student activists travel to South America to protest the destruction of the rainforest and quickly find themselves captured by the indigenous peoples who live there.
While some horror movies are hard to get through due to their terrifying nature, this was not completely true for The Green Inferno. Instead, many people struggled to finish it due to its controversial elements (including how the movie depicted indigenous peoples and their culture). Some also struggled to get through it for its excessive violence and weak plot. While Eli Roth has certainly made some memorable horror movies in the past, this was definitely not his best work.
Hereditary (2018)
Bursting on the scene as one of the most original horror films in years, Hereditary was as cinematic as it was terrifying. While dealing with the death of the matriarch, a grieving family is plagued by a series of horrific, and possibly supernatural events.
While also making subtle statements about grief and loss, director Ari Aster delivered some of horror cinema’s scariest moments. Pulling its inspiration from many film sources, Hereditary builds its tension slowly until the entire thing explodes in a shower of surreal horror, with a ghostly slant. What makes the film so scary is that it finds many ways to frighten its audience, and the viewer is constantly kept guessing as to what will happen next.
Ringu (1998)
While most fans are familiar with the American remake from several years later, Ringu stands head and shoulders above its copy. A journalist and her husband fall down a dark rabbit hole while investigating a mysterious videotape that is said to kill the person that watches it within seven days.
RELATED: The 14 Best Horror Movies Of The Last Five Years, According To Reddit
With its unique, J-Horror style, Ringu slowly builds its creepy tension until the viewer is practically crawling in their seat with fright. The film combines its slow pace with shocking moments of terror keep the audience off-balance throughout. One of the scariest aspects of the film is that the locations are all very plain and it is clear that the events of the story could happen anywhere.
Ju-On: The Grudge (2002)
Proving to be one of the best Japanese horror films of all time, Ju-on: The Grudge pushed the boundaries of what was possible in supernatural horror. A volunteer social worker is assigned to look into a case and finds that she is haunted by a vengeful spirit that resides in the house she visited.
Drawing its ghost designs from Japanese folklore, The Grudge‘s terrifying spirits are quite simple and yet effective. Using sound, along with visuals, the film ratchets up the terror by introducing frightening children. The film was so effective with its terror that even the watered down, American remake is horrifying.
The Conjuring (2013)
Supposedly drawing its story from the case files of paranormal investigators Ed and Lorraine Warren, The Conjuring added another dimension to the supernatural. Called to help out, two noted paranormal researchers attempt to free a family from a supernatural force that is occupying their farmhouse.
Combining elements of ghost stories with demonic possession, The Conjuring opened the door to a whole new cinematic world of terror. While its sequels went in strange directions, the original film is down-to-earth with its approach and slowly builds suspense throughout. Using the medium of film to showcase strange and frightening visuals, the film is a slow burn with a big payoff.
Insidious (2010)
Taking the ghost story in new directions was a difficult task, but Insidious quickly proved it was still possible to showcase an entirely new vision in horror. A family recruits a psychic’s help when they begin to suspect that their comatose son may be trapped in a frightening netherworld known as The Further.
Variety is the name of the game when it comes to Insidious, and the movie provides a wealth of frightening ghosts throughout. Not relying exclusively on one character design, the ghouls in the film are numerous, and each reflects certain primal fears that the audience has. Building slowly, the film’s climax plunges the viewer into the terrifying world of The Further for even more chills.
The Descent (2005)
Monsters are scary enough, but by adding in an element of claustrophobia to its mix, The Descent proved to be a terrifying tale. A group of friends go on a spelunking expedition through a series of caves. Things take a dark turn when they are trapped inside and find themselves pursued by a group of subterranean human-like predators.
RELATED: The 10 Best Period Horror Movies, Ranked By Rotten Tomatoes
Benefiting from its creepy uses of sound, The Descent is best enjoyed in silence and will surely have the audience’s skin-crawling throughout. The film is essentially a tale of two horrors as the first half plays on many viewers’ fears of confined spaces, and second on more primal fears of death.
The Exorcist (1973)
When discussing the scariest films of all time, one movie has consistently been in the conversation since its release. The Exorcist is the story of a young girl named Reagan who is possessed by a demon and must be exorcised by a grieving priest and a mysterious priest, who is an expert in demons.
Every aspect of The Exorcist is dripping with fright, from its creepy soundtrack to the horrifying visual of a possessed little girl. Director William Friedkin’s realistic style of filmmaking only helps to add to the terror as things go from bad to worse throughout. While the stories were conflated for promotional purposes, The Exorcist had viewers literally running from the theaters in terror when it was first released.
The Human Centipede 2 (2011)
Coming as a follow-up to the ultimate dare film, The Human Centipede, the sequel brought things into reality like no other horror franchise had before. Inspired by the fictional story from the first film, a desperate loner concocts a plan of kidnapping and murder in order to recreate the fictional doctor’s evil deeds.
Given that the movie is banned in several countries, including the UK, for being “potentially obscene and sexually violent” (via The Hollywood Reporter), it’s not surprising that some struggle to even go near the movie. Not only had the first movie been deemed controversial because of its excessive violence and unnecessary graphic images but even critics struggled to review it (including Roger Ebert). It’s certainly not a movie that fans will be rewatching in a hurry.
NEXT: The 10 Best Horror Movies, Ranked By The AFI
Wonder Twins HBO Max DC Movie Casts Riverdale & 1883 Stars
About The Author
Dalton Norman (176 Articles Published)
Dalton is a freelance writer and novelist from Orlando Florida. He currently lives in Los Angeles and pursues writing full time. He is an avid reader and film buff.
More From Dalton Norman
We would like to say thanks to the author of this post for this incredible web content
)
[summary] => Content Warning: This article contains graphic references and discussions of racism Now that horror auteur Jordan Peele is returning to the big screen with his new film Nope, audiences are guaranteed to get a healthy dose of terror that will send them fleeing from the theater. The horror genre has spooked viewers since the beginning of film history, ... Read more
[atom_content] =>
Content Warning: This article contains graphic references and discussions of racism
Now that horror auteur Jordan Peele is returning to the big screen with his new film Nope, audiences are guaranteed to get a healthy dose of terror that will send them fleeing from the theater. The horror genre has spooked viewers since the beginning of film history, but certain movies have found a way to scare as much of their audience as possible.
RELATED: 10 Most Confusing Horror Movies, According To Reddit
Whether its supernatural horror like in The Conjuring, or downright gross films like The Human Centipede 2, some films push viewers to their absolute breaking point. Though there are many classic chillers, users on Ranker took to the site to vote for the films that they were too scared to finish watching.
SCREENRANT VIDEO OF THE DAY
It (1990)
Generally considered one of Stephen King’s best TV adaptations, It attempted to capture one of the author’s densest tomes. Set in the 1960s and 1990s, a group of friends band together to stop a mysterious and deadly being that manifests itself as a clown named Pennywise.
Essentially sparking the “scary clown” phase of horror, King’s story featured a wide variety of interesting characters and freaky scenes. Because so many viewers saw It when they were younger, a lot of the scariest moments have stuck with fans over three decades since the TV movie’s release.
The Green Inferno (2013)
Attempting to recreate the magic of classic grindhouse horror films like Cannibal Holocaust, Eli Roth’s The Green Inferno took its horrors to the jungles of the Amazon. A group of student activists travel to South America to protest the destruction of the rainforest and quickly find themselves captured by the indigenous peoples who live there.
While some horror movies are hard to get through due to their terrifying nature, this was not completely true for The Green Inferno. Instead, many people struggled to finish it due to its controversial elements (including how the movie depicted indigenous peoples and their culture). Some also struggled to get through it for its excessive violence and weak plot. While Eli Roth has certainly made some memorable horror movies in the past, this was definitely not his best work.
Hereditary (2018)
Bursting on the scene as one of the most original horror films in years, Hereditary was as cinematic as it was terrifying. While dealing with the death of the matriarch, a grieving family is plagued by a series of horrific, and possibly supernatural events.
While also making subtle statements about grief and loss, director Ari Aster delivered some of horror cinema’s scariest moments. Pulling its inspiration from many film sources, Hereditary builds its tension slowly until the entire thing explodes in a shower of surreal horror, with a ghostly slant. What makes the film so scary is that it finds many ways to frighten its audience, and the viewer is constantly kept guessing as to what will happen next.
Ringu (1998)
While most fans are familiar with the American remake from several years later, Ringu stands head and shoulders above its copy. A journalist and her husband fall down a dark rabbit hole while investigating a mysterious videotape that is said to kill the person that watches it within seven days.
RELATED: The 14 Best Horror Movies Of The Last Five Years, According To Reddit
With its unique, J-Horror style, Ringu slowly builds its creepy tension until the viewer is practically crawling in their seat with fright. The film combines its slow pace with shocking moments of terror keep the audience off-balance throughout. One of the scariest aspects of the film is that the locations are all very plain and it is clear that the events of the story could happen anywhere.
Ju-On: The Grudge (2002)
Proving to be one of the best Japanese horror films of all time, Ju-on: The Grudge pushed the boundaries of what was possible in supernatural horror. A volunteer social worker is assigned to look into a case and finds that she is haunted by a vengeful spirit that resides in the house she visited.
Drawing its ghost designs from Japanese folklore, The Grudge‘s terrifying spirits are quite simple and yet effective. Using sound, along with visuals, the film ratchets up the terror by introducing frightening children. The film was so effective with its terror that even the watered down, American remake is horrifying.
The Conjuring (2013)
Supposedly drawing its story from the case files of paranormal investigators Ed and Lorraine Warren, The Conjuring added another dimension to the supernatural. Called to help out, two noted paranormal researchers attempt to free a family from a supernatural force that is occupying their farmhouse.
Combining elements of ghost stories with demonic possession, The Conjuring opened the door to a whole new cinematic world of terror. While its sequels went in strange directions, the original film is down-to-earth with its approach and slowly builds suspense throughout. Using the medium of film to showcase strange and frightening visuals, the film is a slow burn with a big payoff.
Insidious (2010)
Taking the ghost story in new directions was a difficult task, but Insidious quickly proved it was still possible to showcase an entirely new vision in horror. A family recruits a psychic’s help when they begin to suspect that their comatose son may be trapped in a frightening netherworld known as The Further.
Variety is the name of the game when it comes to Insidious, and the movie provides a wealth of frightening ghosts throughout. Not relying exclusively on one character design, the ghouls in the film are numerous, and each reflects certain primal fears that the audience has. Building slowly, the film’s climax plunges the viewer into the terrifying world of The Further for even more chills.
The Descent (2005)
Monsters are scary enough, but by adding in an element of claustrophobia to its mix, The Descent proved to be a terrifying tale. A group of friends go on a spelunking expedition through a series of caves. Things take a dark turn when they are trapped inside and find themselves pursued by a group of subterranean human-like predators.
RELATED: The 10 Best Period Horror Movies, Ranked By Rotten Tomatoes
Benefiting from its creepy uses of sound, The Descent is best enjoyed in silence and will surely have the audience’s skin-crawling throughout. The film is essentially a tale of two horrors as the first half plays on many viewers’ fears of confined spaces, and second on more primal fears of death.
The Exorcist (1973)
When discussing the scariest films of all time, one movie has consistently been in the conversation since its release. The Exorcist is the story of a young girl named Reagan who is possessed by a demon and must be exorcised by a grieving priest and a mysterious priest, who is an expert in demons.
Every aspect of The Exorcist is dripping with fright, from its creepy soundtrack to the horrifying visual of a possessed little girl. Director William Friedkin’s realistic style of filmmaking only helps to add to the terror as things go from bad to worse throughout. While the stories were conflated for promotional purposes, The Exorcist had viewers literally running from the theaters in terror when it was first released.
The Human Centipede 2 (2011)
Coming as a follow-up to the ultimate dare film, The Human Centipede, the sequel brought things into reality like no other horror franchise had before. Inspired by the fictional story from the first film, a desperate loner concocts a plan of kidnapping and murder in order to recreate the fictional doctor’s evil deeds.
Given that the movie is banned in several countries, including the UK, for being “potentially obscene and sexually violent” (via The Hollywood Reporter), it’s not surprising that some struggle to even go near the movie. Not only had the first movie been deemed controversial because of its excessive violence and unnecessary graphic images but even critics struggled to review it (including Roger Ebert). It’s certainly not a movie that fans will be rewatching in a hurry.
NEXT: The 10 Best Horror Movies, Ranked By The AFI
Wonder Twins HBO Max DC Movie Casts Riverdale & 1883 Stars
About The Author
Dalton Norman (176 Articles Published)
Dalton is a freelance writer and novelist from Orlando Florida. He currently lives in Los Angeles and pursues writing full time. He is an avid reader and film buff.
More From Dalton Norman
We would like to say thanks to the author of this post for this incredible web content
[date_timestamp] => 1650088783
)
[4] => Array
(
[title] => Se conocieron los violentos mensajes que Johnny Depp envió a su amigo sobre Amber Heard
[link] => https://bestmovies.movs.world/healthandscience/se-conocieron-los-violentos-mensajes-que-johnny-depp-envio-a-su-amigo-sobre-amber-heard/
[dc] => Array
(
[creator] => Pauline Moonlky
)
[pubdate] => Sat, 16 Apr 2022 05:12:55 +0000
[category] => Health And ScienceAmberamigoconocieronDeppenvióheardJohnnyLosmensajessobreviolentos
[guid] => https://bestmovies.movs.world/?p=106889
[description] => El juicio por difamación de Johnny Depp contra su ex esposa Amber Heard continúa, con un nuevo episodio a esta novela mediática que parece no acabar nunca. La pareja que se separó en 2016 tras un año de matrimonio, se encuentra nuevamente ante la justicia. El actor de Piratas del Caribe denunció a Heard por difamación, ... Read more
[content] => Array
(
[encoded] =>
El juicio por difamación de Johnny Depp contra su ex esposa Amber Heard continúa, con un nuevo episodio a esta novela mediática que parece no acabar nunca. La pareja que se separó en 2016 tras un año de matrimonio, se encuentra nuevamente ante la justicia.
El actor de Piratas del Caribe denunció a Heard por difamación, luego de la publicación de un artículo que la actriz hizo en 2018 en The Washington Post, donde se describía a sí misma como una víctima de abuso doméstico. Si bien el nombre del actor no era mencionado en dicha publicación, Depp alega que dichas declaraciones han llevado su carrera a la ruina.
El pasado martes 12 de abril comenzó en Fairfax, Virgina, donde ambas partes se encuentran presentes y exponiendo evidencia de lo que fue su relación mientras estuvieron casados. Depp niega haber abusado de Heard, pero los abogados de ella indican que la evidencia probará lo contrario. Las negaciones del actor, argumentan, carecen de credibilidad debido a que frecuentemente bebía y hacía uso de sustancias que lo llevaban a perder el conocimiento.
En las últimas horas se conocieron los mensajes que el actor envió a un amigo sobre Amber Heard. Durante el juicio, se leyó el presunto mensaje de texto entre Johnny y su amigo y vecino Isaac Baruch, quien declaró en la corte.
“Espero que el cadáver podrido de Amber se esté descomponiendo en el jodido baúl de un honda civic?, habría escrito Depp a Baruch en 2016.
Este no es el único mensaje privado que se reveló en la Corte, ya que también se difundieron los supuestos mensajes que Heard le envió a su madre. “Es terrible, mamá. No sé qué hacer”. Otro mensaje decía: “Está loco, mamá. Violento y loco. Estoy destrozada que esto es a quien amo”, se lee en uno de los mensajes.
“Siento que estoy en un tren que va muy rápido y que está a punto de explotar, pero no quiero saltar y dejar atrás a mi amor. Así que me quedo en el tren, aunque sé que está a punto de explotar”, decía otro de los mensajes que se leyeron en voz alta durante el juicio.
Al respecto de estos mensajes Amber explicó que en ese momento estaba muy enamorada de Johnny, ya que durante el tiempo en que él se había mantenido sobrio y limpio era una persona generosa, amorosa y notable. “Lo amaba y no quería perder eso? el otro lado de él era un monstruo, pero siempre tuve la esperanza de que estuviera limpio y sobrio”, dijo la actriz en relación a los mensajes enviados a su difunta madre.
Depp niega las acusaciones de su ex
La actriz también declaró que en ese entonces solo pudo confiarle a su madre lo que estaba atravesando, pero que no pudo contarle a su padre. Debido a que nunca le había tocado atravesar una situación semejante, tenía miedo de contarle a su padre y que este reaccionara de forma violenta hacia Johnny y la situación se agravara aún más.
Otro de los testigos que testificó el día jueves fue Laurel Anderson, la ex consejera matrimonial de la pareja que se reunió con ellos juntos y por separado y tomó notas sobre sus sesiones. La profesional explicó que ambas partes estaban involucrados en un “abuso mutuo” iniciado por uno u otro, en parte, como resultado de sus experiencias pasadas.
Se espera que tanto Depp como Heard testifiquen en el juicio, que tiene previsto una duración de seis semanas. Asimismo podrían ser llamados a declarar los actores Paul Bettany y James Franco, como testigos de las partes, y el empresario tecnológico Elon Musk, quien estuvo en pareja con Heard.
Dejanos tu mensaje con tu opinión o comentario sobre alguna serie, película o programa. ¿Qué te gustaría leer sobre celebridades, películas, series o plataformas? ¡No dejes de escribirnos a contacto@quever.news!
We want to thank the writer of this write-up for this incredible web content
)
[summary] => El juicio por difamación de Johnny Depp contra su ex esposa Amber Heard continúa, con un nuevo episodio a esta novela mediática que parece no acabar nunca. La pareja que se separó en 2016 tras un año de matrimonio, se encuentra nuevamente ante la justicia. El actor de Piratas del Caribe denunció a Heard por difamación, ... Read more
[atom_content] =>
El juicio por difamación de Johnny Depp contra su ex esposa Amber Heard continúa, con un nuevo episodio a esta novela mediática que parece no acabar nunca. La pareja que se separó en 2016 tras un año de matrimonio, se encuentra nuevamente ante la justicia.
El actor de Piratas del Caribe denunció a Heard por difamación, luego de la publicación de un artículo que la actriz hizo en 2018 en The Washington Post, donde se describía a sí misma como una víctima de abuso doméstico. Si bien el nombre del actor no era mencionado en dicha publicación, Depp alega que dichas declaraciones han llevado su carrera a la ruina.
El pasado martes 12 de abril comenzó en Fairfax, Virgina, donde ambas partes se encuentran presentes y exponiendo evidencia de lo que fue su relación mientras estuvieron casados. Depp niega haber abusado de Heard, pero los abogados de ella indican que la evidencia probará lo contrario. Las negaciones del actor, argumentan, carecen de credibilidad debido a que frecuentemente bebía y hacía uso de sustancias que lo llevaban a perder el conocimiento.
En las últimas horas se conocieron los mensajes que el actor envió a un amigo sobre Amber Heard. Durante el juicio, se leyó el presunto mensaje de texto entre Johnny y su amigo y vecino Isaac Baruch, quien declaró en la corte.
“Espero que el cadáver podrido de Amber se esté descomponiendo en el jodido baúl de un honda civic?, habría escrito Depp a Baruch en 2016.
Este no es el único mensaje privado que se reveló en la Corte, ya que también se difundieron los supuestos mensajes que Heard le envió a su madre. “Es terrible, mamá. No sé qué hacer”. Otro mensaje decía: “Está loco, mamá. Violento y loco. Estoy destrozada que esto es a quien amo”, se lee en uno de los mensajes.
“Siento que estoy en un tren que va muy rápido y que está a punto de explotar, pero no quiero saltar y dejar atrás a mi amor. Así que me quedo en el tren, aunque sé que está a punto de explotar”, decía otro de los mensajes que se leyeron en voz alta durante el juicio.
Al respecto de estos mensajes Amber explicó que en ese momento estaba muy enamorada de Johnny, ya que durante el tiempo en que él se había mantenido sobrio y limpio era una persona generosa, amorosa y notable. “Lo amaba y no quería perder eso? el otro lado de él era un monstruo, pero siempre tuve la esperanza de que estuviera limpio y sobrio”, dijo la actriz en relación a los mensajes enviados a su difunta madre.
Depp niega las acusaciones de su ex
La actriz también declaró que en ese entonces solo pudo confiarle a su madre lo que estaba atravesando, pero que no pudo contarle a su padre. Debido a que nunca le había tocado atravesar una situación semejante, tenía miedo de contarle a su padre y que este reaccionara de forma violenta hacia Johnny y la situación se agravara aún más.
Otro de los testigos que testificó el día jueves fue Laurel Anderson, la ex consejera matrimonial de la pareja que se reunió con ellos juntos y por separado y tomó notas sobre sus sesiones. La profesional explicó que ambas partes estaban involucrados en un “abuso mutuo” iniciado por uno u otro, en parte, como resultado de sus experiencias pasadas.
Se espera que tanto Depp como Heard testifiquen en el juicio, que tiene previsto una duración de seis semanas. Asimismo podrían ser llamados a declarar los actores Paul Bettany y James Franco, como testigos de las partes, y el empresario tecnológico Elon Musk, quien estuvo en pareja con Heard.
Dejanos tu mensaje con tu opinión o comentario sobre alguna serie, película o programa. ¿Qué te gustaría leer sobre celebridades, películas, series o plataformas? ¡No dejes de escribirnos a contacto@quever.news!
We want to thank the writer of this write-up for this incredible web content
[date_timestamp] => 1650085975
)
[5] => Array
(
[title] => Exercise during pregnancy reduces the risk of Type-2 Diabetes in offspring
[link] => https://bestmovies.movs.world/healthandscience/exercise-during-pregnancy-reduces-the-risk-of-type-2-diabetes-in-offspring/
[dc] => Array
(
[creator] => Tony Grantly
)
[pubdate] => Sat, 16 Apr 2022 05:11:38 +0000
[category] => Health And SciencediabetesExerciseoffspringpregnancyreducesrisktype2
[guid] => https://bestmovies.movs.world/?p=106884
[description] => Journal Reference: Joji Kusuyama, Nathan S. Makarewicz, Brent G. Albertson, Ana Barbara Alves-Wagner, Royce H. Conlin, Noah B Prince, Christiano R. R. Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F. Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S. Nozik, Laurie J. Goodyear. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat ... Read more
[content] => Array
(
[encoded] =>
Journal Reference:
Joji Kusuyama, Nathan S. Makarewicz, Brent G. Albertson, Ana Barbara Alves-Wagner, Royce H. Conlin, Noah B Prince, Christiano R. R. Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F. Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S. Nozik, Laurie J. Goodyear. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes, 2022; DOI: 10.2337/db21-0706
The results were published in the Journal Diabetes on March 15, 2022.
A worrying trend
Maternal obesity and type 2 diabetes are on the rise. Over 30% of women of childbearing age in Western and Asian countries are classified as obese. Meanwhile, 630 million people are expected to be living with type 2 diabetes by 2045. Children born to obese mothers or mothers with type 2 diabetes have an increased risk of diabetes, even after going on to live healthy lives.
?With the growth of maternal obesity, a worrying cycle is forming where the risks of diabetes gets passed down from generation to generation,? says assistant professor Joji Kusuyama from Tohoku University?s Interdisciplinary Institute for Frontier Sciences (FRIS), and lead author of the study. ?Stopping this cycle is a critical and pressing medical problem.?
In the research group with Kusuyama was Laurie Goodyear, Nathan Makarewicz, Brent Albertson, Ana Alves-Wagner, Royce Conlin, Noah Prince, Christiano Alves, Krithika Ramachandran, and Michael Hirshman from the Joslin Diabetes Center; Chisayo Kozuka from RIKEN?s Center for Integrative Medical Sciences; Toshihisa Hatta from Kanazawa?s Medical University; Yang Xiudong and Yang Xia from the University of Texas at Houston; and Ryoichi Nagatomi from Tohoku University?s Graduate School of Biomedical Engineering.
Previously, the group showed that exercise during pregnancy has tremendous benefits on an offspring?s metabolic health, demonstrating that placenta-derived SOD3, which stands for supuroexide dismutase 3, plays a key role in transmitting the benefits of maternal exercise to the offspring. Building on this, the team set out to understand how SOD3 prevents the negative effects of obesity being passed from mother to child and found that SOD3 inhibited high-fat diet-induced abnormalities in the offspring?s glucose metabolism.
The link between maternal and childhood obesity
Histone methylation plays a fundamental role in epigenetic modification ? heritable changes to strands of DNA that do not affect the inherited base pairs. Methyl group (-CH3) attaches to an amino acid in the tail of histone proteins that wrap DNA, sometimes activating gene expression, sometimes inhibiting it.
When a mother consumes a diet heavy in fat, the histone H3 trimethylation H3K4me3 gets decreased in the fetal liver and hinders the expression of glucose metabolism genes.
This, the researchers discovered, is caused by two things. Reactive oxygen species (ROS) ? oxygen in a reactivated and activated state which aids the body?s metabolism and cellular functions ? becomes elevated. Meanwhile, WDR82, a key protein that regulates histone methyltransferase, becomes oxidative, impairing protein functions.
The harmful effects of a maternal high-fat diet on an offspring?s metabolism are reversed by maternal exercise. Genetic manipulation demonstrated that placental SOD3 is indispensable for the protective effects of maternal exercise on offspring.
The study also highlighted how crucial exercise is for negating this. When the researchers infused N-acetylcysteine (NAC), an antioxidant that boosts performance in the liver, into the fetal liver, it did not reproduce the results of SOD3. This suggests the naturally produced SOD3 from exercise during pregnancy is pivotal for the offspring?s metabolic wellbeing.
Implications for the future
Given the simplicity and cost-effectiveness of exercise, encouraging mothers to exercise could help reverse the alarming rates of obesity and type-2 diabetes. The merits of SOD3 may not be limited to the metabolism stresses Kusuyama. ?There may be wider benefits of this protein on other organs in the child. We are currently looking into the modifications in placenta tissue brought about by SOD3 that may have positive lifelong impacts on children.?
The authors caution the study is only at the preclinical stage and its applicability to humans requires further studies. Additionally, certain aspects of the signaling pathway require further investigation.
We would like to say thanks to the writer of this write-up for this remarkable material
)
[summary] => Journal Reference: Joji Kusuyama, Nathan S. Makarewicz, Brent G. Albertson, Ana Barbara Alves-Wagner, Royce H. Conlin, Noah B Prince, Christiano R. R. Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F. Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S. Nozik, Laurie J. Goodyear. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat ... Read more
[atom_content] =>
Journal Reference:
Joji Kusuyama, Nathan S. Makarewicz, Brent G. Albertson, Ana Barbara Alves-Wagner, Royce H. Conlin, Noah B Prince, Christiano R. R. Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F. Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S. Nozik, Laurie J. Goodyear. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes, 2022; DOI: 10.2337/db21-0706
The results were published in the Journal Diabetes on March 15, 2022.
A worrying trend
Maternal obesity and type 2 diabetes are on the rise. Over 30% of women of childbearing age in Western and Asian countries are classified as obese. Meanwhile, 630 million people are expected to be living with type 2 diabetes by 2045. Children born to obese mothers or mothers with type 2 diabetes have an increased risk of diabetes, even after going on to live healthy lives.
?With the growth of maternal obesity, a worrying cycle is forming where the risks of diabetes gets passed down from generation to generation,? says assistant professor Joji Kusuyama from Tohoku University?s Interdisciplinary Institute for Frontier Sciences (FRIS), and lead author of the study. ?Stopping this cycle is a critical and pressing medical problem.?
In the research group with Kusuyama was Laurie Goodyear, Nathan Makarewicz, Brent Albertson, Ana Alves-Wagner, Royce Conlin, Noah Prince, Christiano Alves, Krithika Ramachandran, and Michael Hirshman from the Joslin Diabetes Center; Chisayo Kozuka from RIKEN?s Center for Integrative Medical Sciences; Toshihisa Hatta from Kanazawa?s Medical University; Yang Xiudong and Yang Xia from the University of Texas at Houston; and Ryoichi Nagatomi from Tohoku University?s Graduate School of Biomedical Engineering.
Previously, the group showed that exercise during pregnancy has tremendous benefits on an offspring?s metabolic health, demonstrating that placenta-derived SOD3, which stands for supuroexide dismutase 3, plays a key role in transmitting the benefits of maternal exercise to the offspring. Building on this, the team set out to understand how SOD3 prevents the negative effects of obesity being passed from mother to child and found that SOD3 inhibited high-fat diet-induced abnormalities in the offspring?s glucose metabolism.
The link between maternal and childhood obesity
Histone methylation plays a fundamental role in epigenetic modification ? heritable changes to strands of DNA that do not affect the inherited base pairs. Methyl group (-CH3) attaches to an amino acid in the tail of histone proteins that wrap DNA, sometimes activating gene expression, sometimes inhibiting it.
When a mother consumes a diet heavy in fat, the histone H3 trimethylation H3K4me3 gets decreased in the fetal liver and hinders the expression of glucose metabolism genes.
This, the researchers discovered, is caused by two things. Reactive oxygen species (ROS) ? oxygen in a reactivated and activated state which aids the body?s metabolism and cellular functions ? becomes elevated. Meanwhile, WDR82, a key protein that regulates histone methyltransferase, becomes oxidative, impairing protein functions.
The harmful effects of a maternal high-fat diet on an offspring?s metabolism are reversed by maternal exercise. Genetic manipulation demonstrated that placental SOD3 is indispensable for the protective effects of maternal exercise on offspring.
The study also highlighted how crucial exercise is for negating this. When the researchers infused N-acetylcysteine (NAC), an antioxidant that boosts performance in the liver, into the fetal liver, it did not reproduce the results of SOD3. This suggests the naturally produced SOD3 from exercise during pregnancy is pivotal for the offspring?s metabolic wellbeing.
Implications for the future
Given the simplicity and cost-effectiveness of exercise, encouraging mothers to exercise could help reverse the alarming rates of obesity and type-2 diabetes. The merits of SOD3 may not be limited to the metabolism stresses Kusuyama. ?There may be wider benefits of this protein on other organs in the child. We are currently looking into the modifications in placenta tissue brought about by SOD3 that may have positive lifelong impacts on children.?
The authors caution the study is only at the preclinical stage and its applicability to humans requires further studies. Additionally, certain aspects of the signaling pathway require further investigation.
We would like to say thanks to the writer of this write-up for this remarkable material
[date_timestamp] => 1650085898
)
[6] => Array
(
[title] => Por qué Johnny Depp es mejor que Mads Mikkelsen como Grindelwald en la saga ?Animales fantásticos?
[link] => https://bestmovies.movs.world/healthandscience/por-que-johnny-depp-es-mejor-que-mads-mikkelsen-como-grindelwald-en-la-saga-animales-fantasticos/
[dc] => Array
(
[creator] => Tom Pauler
)
[pubdate] => Sat, 16 Apr 2022 04:57:34 +0000
[category] => Health And ScienceAnimalesComoDeppfantásticosGrindelwaldJohnnyMadsMejorMikkelsenporquésaga
[guid] => https://bestmovies.movs.world/?p=106878
[description] => El reciente estreno de ‘Animales fantásticos: Los secretos de Dumbledore’ nos ha permitido comprobar hasta qué punto fue o no un acierto elegir a Mads Mikkelsen para sustituir a Johnny Depp en el papel de Grindelwald. No son pocos los que han alabado a Mikkelsen por encima de Depp, pero yo creo todo lo contrario ... Read more
[content] => Array
(
[encoded] =>
El reciente estreno de ‘Animales fantásticos: Los secretos de Dumbledore’ nos ha permitido comprobar hasta qué punto fue o no un acierto elegir a Mads Mikkelsen para sustituir a Johnny Depp en el papel de Grindelwald. No son pocos los que han alabado a Mikkelsen por encima de Depp, pero yo creo todo lo contrario y que fue un error forzar la salida del protagonista de ‘La novena puerta’.
No es la primera vez, ni será la última, que una superproducción de Hollywood ficha a Mikkelsen para dar vida al gran villano de la función. Su rostro inconfundible se presta mucho a ello, pero a la hora de la verdad le han dado muchos personajes de malvado que no van mucho más allá de lo genérico. Mucho me temo que algo parecido sucede en ‘Animales fantásticos: Los secretos de Dumbledore’.
Puede que haya algún pequeño spoiler de la saga de aquí en adelante
Mikkelsen contra Depp
A nadie le sorprende que Mikkelsen opte por una visión bastante más reposada de Grindelwald que la ofrecida en su momento por Depp, pero lo cierto es que se trata de un cambio notable sin que haya nada dentro de la propia película que lo justifique. El personaje era mucho más expresivo en ‘Animales fantásticos: Los crímenes de Grindelwald’, sin que ello supusiera que el actor diera rienda suelta a esos excesos tan inspirados en su inolvidable Jack Sparrow.
Lo cierto es que la maldad de Grindelwald en la segunda entrega estaba más trabajada, siendo capaz de impresionar tanto de una forma más contenida como cuando tocaba coquetear un poco con lo caricaturesco. Realmente era algo que destacaba en la película y permitía sentar las bases de un villano que prometía darnos más alegrías que Voldemort. Nada en contra de este último, que como representación de la maldad pura estaba muy conseguido, pero siempre se agradece un poco más de variedad.
Además, ‘Animales fantásticos: Los crímenes de Grindelwald’ allanaba el camino para ver a un personaje más desatado según iba creciendo su poder en la comunidad mágica, pero en ‘Los secretos de Dumbledore’ se opta por una aproximación diferente, como si quisieran vincularlo con la idea de ser un líder fascista que echa mano del populismo para ascender al poder.
Por ello, Grindelwald en ‘Los secretos de Dumbledore’ es una especie de eterna promesa de algo tremendo que luego nunca llega, tanto en las relaciones individuales -cuesta creer que no tenga problemas en darle varias oportunidades al personaje interpretado por Ezra Miller antes sus repetidos fracasos- como en su aspiración por controlar el mundo.
Eso lleva a que sus intentos de imponer respeto y miedo con su presencia se desdibujen. Es verdad que no ayuda que ‘Los secretos de Dumbledore’ no deje de ser una aventura de transición, pero es que ‘Los crímenes de Grindelwald’ tampoco iba más allá de una presentación real del personaje tras la treta que ejecutaba en ‘Animales fantásticos y dónde encontrarlos’, donde Colin Farrell estaba muy convincente hasta que la verdad salía a la luz.
De esta forma, el Grindelwald de Mikkelsen es un villano más, perdiendo por el camino todo lo que hacía llamativo a la versión de Depp. Entiendo a aquellos que no disfrutasen con la interpretación de este último -y también que Mikkelsen no quisiera limitarse a copiar lo que hizo Depp-, pero al menos proponía algo diferente y con más matices, mientras que el protagonista de ‘Otra ronda’ se limita a intentar dar ciertos toques de realismo a un personaje que pedía mucho más que eso. A fin de cuentas, estamos en el universo mágico por excelencia de la historia del cine.
We wish to thank the author of this article for this awesome content
)
[summary] => El reciente estreno de ‘Animales fantásticos: Los secretos de Dumbledore’ nos ha permitido comprobar hasta qué punto fue o no un acierto elegir a Mads Mikkelsen para sustituir a Johnny Depp en el papel de Grindelwald. No son pocos los que han alabado a Mikkelsen por encima de Depp, pero yo creo todo lo contrario ... Read more
[atom_content] =>
El reciente estreno de ‘Animales fantásticos: Los secretos de Dumbledore’ nos ha permitido comprobar hasta qué punto fue o no un acierto elegir a Mads Mikkelsen para sustituir a Johnny Depp en el papel de Grindelwald. No son pocos los que han alabado a Mikkelsen por encima de Depp, pero yo creo todo lo contrario y que fue un error forzar la salida del protagonista de ‘La novena puerta’.
No es la primera vez, ni será la última, que una superproducción de Hollywood ficha a Mikkelsen para dar vida al gran villano de la función. Su rostro inconfundible se presta mucho a ello, pero a la hora de la verdad le han dado muchos personajes de malvado que no van mucho más allá de lo genérico. Mucho me temo que algo parecido sucede en ‘Animales fantásticos: Los secretos de Dumbledore’.
Puede que haya algún pequeño spoiler de la saga de aquí en adelante
Mikkelsen contra Depp
A nadie le sorprende que Mikkelsen opte por una visión bastante más reposada de Grindelwald que la ofrecida en su momento por Depp, pero lo cierto es que se trata de un cambio notable sin que haya nada dentro de la propia película que lo justifique. El personaje era mucho más expresivo en ‘Animales fantásticos: Los crímenes de Grindelwald’, sin que ello supusiera que el actor diera rienda suelta a esos excesos tan inspirados en su inolvidable Jack Sparrow.
Lo cierto es que la maldad de Grindelwald en la segunda entrega estaba más trabajada, siendo capaz de impresionar tanto de una forma más contenida como cuando tocaba coquetear un poco con lo caricaturesco. Realmente era algo que destacaba en la película y permitía sentar las bases de un villano que prometía darnos más alegrías que Voldemort. Nada en contra de este último, que como representación de la maldad pura estaba muy conseguido, pero siempre se agradece un poco más de variedad.
Además, ‘Animales fantásticos: Los crímenes de Grindelwald’ allanaba el camino para ver a un personaje más desatado según iba creciendo su poder en la comunidad mágica, pero en ‘Los secretos de Dumbledore’ se opta por una aproximación diferente, como si quisieran vincularlo con la idea de ser un líder fascista que echa mano del populismo para ascender al poder.
Por ello, Grindelwald en ‘Los secretos de Dumbledore’ es una especie de eterna promesa de algo tremendo que luego nunca llega, tanto en las relaciones individuales -cuesta creer que no tenga problemas en darle varias oportunidades al personaje interpretado por Ezra Miller antes sus repetidos fracasos- como en su aspiración por controlar el mundo.
Eso lleva a que sus intentos de imponer respeto y miedo con su presencia se desdibujen. Es verdad que no ayuda que ‘Los secretos de Dumbledore’ no deje de ser una aventura de transición, pero es que ‘Los crímenes de Grindelwald’ tampoco iba más allá de una presentación real del personaje tras la treta que ejecutaba en ‘Animales fantásticos y dónde encontrarlos’, donde Colin Farrell estaba muy convincente hasta que la verdad salía a la luz.
De esta forma, el Grindelwald de Mikkelsen es un villano más, perdiendo por el camino todo lo que hacía llamativo a la versión de Depp. Entiendo a aquellos que no disfrutasen con la interpretación de este último -y también que Mikkelsen no quisiera limitarse a copiar lo que hizo Depp-, pero al menos proponía algo diferente y con más matices, mientras que el protagonista de ‘Otra ronda’ se limita a intentar dar ciertos toques de realismo a un personaje que pedía mucho más que eso. A fin de cuentas, estamos en el universo mágico por excelencia de la historia del cine.
We wish to thank the author of this article for this awesome content
[date_timestamp] => 1650085054
)
[7] => Array
(
[title] => Best Easter Movies for Kids to Watch in 2022
[link] => https://bestmovies.movs.world/streaming-services/best-easter-movies-for-kids-to-watch-in-2022/
[dc] => Array
(
[creator] => Sally Scully
)
[pubdate] => Sat, 16 Apr 2022 04:56:37 +0000
[category] => Streaming ServicesEasterkidsMoviesWatch
[guid] => https://bestmovies.movs.world/?p=106872
[description] => Easter is right around the corner. Crazy right? I mean, Christmas was only like a week ago. But no need to sweat how fast the year is flying by when you can hit the CVS candy aisle, gather the whole family together in front of the television, and watch some of the best Easter movies ... Read more
[content] => Array
(
[encoded] =>
Easter is right around the corner. Crazy right? I mean, Christmas was only like a week ago. But no need to sweat how fast the year is flying by when you can hit the CVS candy aisle, gather the whole family together in front of the television, and watch some of the best Easter movies to put you in the holiday spirit. From talking rabbits to iconic dance numbers, these films have all the springtime joy that will make you dread the changing calendar a little less?or for at least 90 minutes.
The best part is you don?t even need to leave your couch. These films can be found on streaming services like Hulu, Apple TV, Netflix, Amazon, Disney+, and HBO Max. It?s a true Easter miracle. Stuff your face with Cadbury eggs and keep reading for 8 of the best Easter movies to watch this year. We?ve got Easter movies for kids, but a few that are fun for the whole family, too.
In this fun-filled, action-packed film, James Corden voices the lovable rascal, Peter Rabbit. When he and his friends get to take over Mr. McGregor?s farm, trouble may or may not ensue. It?s a fast-paced adventure for the whole family featuring a star-studded cast including Rose Byrne, Daisy Ridley, Margot Robbie, and Sam Neill. And if you just can?t get enough of Peter Rabbit, you can also stream the sequel, Peter Rabbit 2, on Netflix!
Where to stream Peter Rabbit
2
Courtesy Everett Collection
No holiday is complete without a Charlie Brown animated special. In It?s the Easter Beagle, Charlie Brown, Linus is back with his crazy conspiracies. No, not the Great Pumpkin. This time we?re talking about an Easter Beagle. It?s a classic that generations of the family can enjoy. Good grief to that!
Stream It’s The Easter Beagle, Charlie Brown on Apple TV+
Easter is all about the bunnies, and we are so here for it. Hop tells the story of E.B (Russell Brand), who is destined to follow in the footsteps of his father, who just so happens to be the Easter Bunny. But that?s a heavy job, and E.B just wants to rock out on the drums. One day, E.B runs away to Hollywood to try and make it big. It?s a zany live-action comedy starring James Marsden, Kaley Cucoco, and David Hasselhoff. This movie will have you singing, laughing, and digging into the nearest bag of jellybeans.
Stream Hop on Netflix
4
Photo: Everett Collection
Speaking of adorable bunnies?.who could forget Judy Hopps? Except, as she would say, she?s not cute. She?s a tough new cop on the job. (But also, she is utterly adorable). Zootopia follows the unlikely team-up between police officer Judy Hopps (Ginnifer Goodwin) and street criminal Nick Wilde (Jason Bateman) as they solve the latest mystery threatening Zootopia. It?s a heartwarming tale full of great celebrity cameos.
Stream Zootopia on Disney+
5
Photo: BBC
For all you action movie fans, this ones for you. In Rise of the Guardians, Santa Claus, the Tooth Fairy, the Easter Bunny, the Sandman, and Jack Frost band together to stop the evil Pitch Black from engulfing the world in darkness in a fight of dreams. Can you name a more epic team-up? I doubt it. Chris Pine, Hugh Jackman, Isla Fisher, and Jude Law bring all the excitement to this film. But the real question is can they save the day? We sure hope so.
Where to stream Rise of the Guardians
6
Disney+
In this wacky animated short, we?re reunited with the Ice Age crew as they prepare for Easter?.because apparently, that was a thing during the Ice Age?? And, of course, there?s an iconic acorn chase. Ray Ramano plays the iconic Manny, and it?s brilliant as always. A lighthearted, short, and sweet watch!
Stream Ice Age: The Great Egg-scapade on Disney+
7
Photo: ABC
Maybe you?re more in the mood for a family rom-com? May I present to you: The Dog Who Saved Easter. When three criminals try to sabotage a dog daycare and Easter, Zeus the dog (voiced by Mario Lopez) leaps into action. Because who says the rabbits get to have all the fun this year? This ones for our beloved canine companions. We see you.
Stream The Dog Who Saved Easter
8
Photo: Everett Collection
Nothing screams family fun like Easter Parade ? and here?s where you can stream it. This musical movie not only stars the iconic Fred Astaire and Judy Garland (kids, ask your parents), but it?s full of colorful dance numbers that will put the right amount of pep into your Easter holiday. When a search for the next big thing thrusts an inexperienced dancer, Hannah, into the limelight, she not only has to prove herself on stage, but she may also be falling in love?? You?ll just have to watch to find out.
We would like to thank the writer of this write-up for this remarkable material
)
[summary] => Easter is right around the corner. Crazy right? I mean, Christmas was only like a week ago. But no need to sweat how fast the year is flying by when you can hit the CVS candy aisle, gather the whole family together in front of the television, and watch some of the best Easter movies ... Read more
[atom_content] =>
Easter is right around the corner. Crazy right? I mean, Christmas was only like a week ago. But no need to sweat how fast the year is flying by when you can hit the CVS candy aisle, gather the whole family together in front of the television, and watch some of the best Easter movies to put you in the holiday spirit. From talking rabbits to iconic dance numbers, these films have all the springtime joy that will make you dread the changing calendar a little less?or for at least 90 minutes.
The best part is you don?t even need to leave your couch. These films can be found on streaming services like Hulu, Apple TV, Netflix, Amazon, Disney+, and HBO Max. It?s a true Easter miracle. Stuff your face with Cadbury eggs and keep reading for 8 of the best Easter movies to watch this year. We?ve got Easter movies for kids, but a few that are fun for the whole family, too.
In this fun-filled, action-packed film, James Corden voices the lovable rascal, Peter Rabbit. When he and his friends get to take over Mr. McGregor?s farm, trouble may or may not ensue. It?s a fast-paced adventure for the whole family featuring a star-studded cast including Rose Byrne, Daisy Ridley, Margot Robbie, and Sam Neill. And if you just can?t get enough of Peter Rabbit, you can also stream the sequel, Peter Rabbit 2, on Netflix!
Where to stream Peter Rabbit
2
Courtesy Everett Collection
No holiday is complete without a Charlie Brown animated special. In It?s the Easter Beagle, Charlie Brown, Linus is back with his crazy conspiracies. No, not the Great Pumpkin. This time we?re talking about an Easter Beagle. It?s a classic that generations of the family can enjoy. Good grief to that!
Stream It’s The Easter Beagle, Charlie Brown on Apple TV+
Easter is all about the bunnies, and we are so here for it. Hop tells the story of E.B (Russell Brand), who is destined to follow in the footsteps of his father, who just so happens to be the Easter Bunny. But that?s a heavy job, and E.B just wants to rock out on the drums. One day, E.B runs away to Hollywood to try and make it big. It?s a zany live-action comedy starring James Marsden, Kaley Cucoco, and David Hasselhoff. This movie will have you singing, laughing, and digging into the nearest bag of jellybeans.
Stream Hop on Netflix
4
Photo: Everett Collection
Speaking of adorable bunnies?.who could forget Judy Hopps? Except, as she would say, she?s not cute. She?s a tough new cop on the job. (But also, she is utterly adorable). Zootopia follows the unlikely team-up between police officer Judy Hopps (Ginnifer Goodwin) and street criminal Nick Wilde (Jason Bateman) as they solve the latest mystery threatening Zootopia. It?s a heartwarming tale full of great celebrity cameos.
Stream Zootopia on Disney+
5
Photo: BBC
For all you action movie fans, this ones for you. In Rise of the Guardians, Santa Claus, the Tooth Fairy, the Easter Bunny, the Sandman, and Jack Frost band together to stop the evil Pitch Black from engulfing the world in darkness in a fight of dreams. Can you name a more epic team-up? I doubt it. Chris Pine, Hugh Jackman, Isla Fisher, and Jude Law bring all the excitement to this film. But the real question is can they save the day? We sure hope so.
Where to stream Rise of the Guardians
6
Disney+
In this wacky animated short, we?re reunited with the Ice Age crew as they prepare for Easter?.because apparently, that was a thing during the Ice Age?? And, of course, there?s an iconic acorn chase. Ray Ramano plays the iconic Manny, and it?s brilliant as always. A lighthearted, short, and sweet watch!
Stream Ice Age: The Great Egg-scapade on Disney+
7
Photo: ABC
Maybe you?re more in the mood for a family rom-com? May I present to you: The Dog Who Saved Easter. When three criminals try to sabotage a dog daycare and Easter, Zeus the dog (voiced by Mario Lopez) leaps into action. Because who says the rabbits get to have all the fun this year? This ones for our beloved canine companions. We see you.
Stream The Dog Who Saved Easter
8
Photo: Everett Collection
Nothing screams family fun like Easter Parade ? and here?s where you can stream it. This musical movie not only stars the iconic Fred Astaire and Judy Garland (kids, ask your parents), but it?s full of colorful dance numbers that will put the right amount of pep into your Easter holiday. When a search for the next big thing thrusts an inexperienced dancer, Hannah, into the limelight, she not only has to prove herself on stage, but she may also be falling in love?? You?ll just have to watch to find out.
We would like to thank the writer of this write-up for this remarkable material
[date_timestamp] => 1650084997
)
[8] => Array
(
[title] => Will Smith Couldn?t Kiss Rosario Dawson Unless Jada Pinkett Smith Was With Him in ?Seven Pounds?
[link] => https://bestmovies.movs.world/movie-actors/will-smith-couldnt-kiss-rosario-dawson-unless-jada-pinkett-smith-was-with-him-in-seven-pounds/
[dc] => Array
(
[creator] => Tom Pauler
)
[pubdate] => Sat, 16 Apr 2022 04:41:34 +0000
[category] => Movie ActorsDawsonJadaKissPinkettPoundsRosarioSmith
[guid] => https://bestmovies.movs.world/?p=106866
[description] => Megastar Will Smith is accustomed to being intimate with his co-stars on screen. But there was a point in Seven Pounds where Smith felt particularly nervous about acting out those close scenes with co-star Rosario Dawson. Because of this, Smith wanted his wife with him while doing the scene. But Jada Pinkett had some choice ... Read more
[content] => Array
(
[encoded] =>
Megastar Will Smith is accustomed to being intimate with his co-stars on screen. But there was a point in Seven Pounds where Smith felt particularly nervous about acting out those close scenes with co-star Rosario Dawson. Because of this, Smith wanted his wife with him while doing the scene. But Jada Pinkett had some choice words for his reaction.
Rosario Dawson remembered how ?Seven Pounds? changed Will Smith
Will Smith and Jada Pinkett Smith | Arturo Holmes/FilmMagic
In Seven Pounds Will Smith plays an IRS agent who offers parts of his body to those in need of a donor. Dawson played Smith?s love interest in the film, but she also previously worked with the Oscar-winner for Men in Black II. Dawson shared that there were a few notable differences between working with Smith on Seven Pounds and their previous film.
?I didn?t recall him having an acting coach on Men in Black II, I could be wrong,? Dawson said in an interview with Vulture. ?Since then, he?s done Ali, so besides punching everything on set, that also gave him a gravitas that he really hadn?t had before. As goofy and fun as he can be, he worked with his acting coach a month before [shooting Seven Pounds].?
But Dawson also felt that starring in Seven Pounds might have had a profound effect on Smith that even his wife noticed.
?And it changed his personality to a certain extent. He was staring at people, to the point of discomfort. We?d have these conversations on set because I became really curious as to whether I was talking to Will or Ben. And I think at times he didn?t even know. It was interesting talking to him about going home and hearing that Jada was telling him, ?You?re driving me crazy! You really need to stop looking at me like that,?? she recalled.
Will Smith didn?t want to kiss Rosario Dawson without Jada Pinkett Smith being with him on the set of ?Seven Pounds?
Dawson revealed that one of the more difficult scenes to get through were their love scenes. If only because, according to her, the Bad Boys star was shy when it was time to get intimate.
?Here is the guy who was pushing our kiss to like the end and the end and the end of the schedule,? Dawson told Access Hollywood. ?So the point was like, ?OK, I know I don?t smell bad? I know I brushed my teeth?I did the deodorant!??
She tried offering Smith words of encouragement to help ease his worries.
?You are just nervous. You?re nervous about kissing me. Don?t worry baby, I?ll be gentle,? she remembered telling him.
Ultimately, Smith only felt better about kissing Dawson if his wife was present. But Jada Pinkett would have some words for Smith before his love scene with Dawson
?He wanted Jada to be on set,? Dawson continued. ?And she was letting him know, ?Baby you really need to bring it! Don?t embarrass me.? So, she was on my side on this one.?
Will Smith had trouble with the ?Seven Pounds? love scene because of how he was raised
Smith would later concede that Dawson was telling the truth about their encounter.
?That?s a lie. All right, that?s a little bit true,? Smith said. ?I like being respectful? [The scene was] a lot like being in a bed and she is naked and you don?t want to accidentally? you know.?
In an interview with Collider, he went into a little more detail about his feelings toward the love scene. He chalked up his reaction to making out with Dawson as a result of his upbringing.
?See with the love?like for me, my grandmother was really firm and?my mother and grandmother?about how men are supposed to treat women,? Smith said.
He would also reveal that he would have the other actor?s thoughts in mind while doing these scenes. This would sometimes distract him.
?So it?s like, for me, my worst nightmare is for an actress to come on my set and feel like I?m taking this as an opportunity to get a little quickie feel, you know, some legal cheating going on. I just need, specifically, women to be comfortable around me,? he elaborated. ?I just don?t want to feel like I?m that dude and doing a love scene and her clothes are off and all of that, it just puts me in my defensive space but it also hurts the acting if I?m in that space.?
RELATED: Body Language Expert Explains if Will Smith?s Oscars Slap Was Fake
We wish to thank the writer of this post for this awesome material
)
[summary] => Megastar Will Smith is accustomed to being intimate with his co-stars on screen. But there was a point in Seven Pounds where Smith felt particularly nervous about acting out those close scenes with co-star Rosario Dawson. Because of this, Smith wanted his wife with him while doing the scene. But Jada Pinkett had some choice ... Read more
[atom_content] =>
Megastar Will Smith is accustomed to being intimate with his co-stars on screen. But there was a point in Seven Pounds where Smith felt particularly nervous about acting out those close scenes with co-star Rosario Dawson. Because of this, Smith wanted his wife with him while doing the scene. But Jada Pinkett had some choice words for his reaction.
Rosario Dawson remembered how ?Seven Pounds? changed Will Smith
Will Smith and Jada Pinkett Smith | Arturo Holmes/FilmMagic
In Seven Pounds Will Smith plays an IRS agent who offers parts of his body to those in need of a donor. Dawson played Smith?s love interest in the film, but she also previously worked with the Oscar-winner for Men in Black II. Dawson shared that there were a few notable differences between working with Smith on Seven Pounds and their previous film.
?I didn?t recall him having an acting coach on Men in Black II, I could be wrong,? Dawson said in an interview with Vulture. ?Since then, he?s done Ali, so besides punching everything on set, that also gave him a gravitas that he really hadn?t had before. As goofy and fun as he can be, he worked with his acting coach a month before [shooting Seven Pounds].?
But Dawson also felt that starring in Seven Pounds might have had a profound effect on Smith that even his wife noticed.
?And it changed his personality to a certain extent. He was staring at people, to the point of discomfort. We?d have these conversations on set because I became really curious as to whether I was talking to Will or Ben. And I think at times he didn?t even know. It was interesting talking to him about going home and hearing that Jada was telling him, ?You?re driving me crazy! You really need to stop looking at me like that,?? she recalled.
Will Smith didn?t want to kiss Rosario Dawson without Jada Pinkett Smith being with him on the set of ?Seven Pounds?
Dawson revealed that one of the more difficult scenes to get through were their love scenes. If only because, according to her, the Bad Boys star was shy when it was time to get intimate.
?Here is the guy who was pushing our kiss to like the end and the end and the end of the schedule,? Dawson told Access Hollywood. ?So the point was like, ?OK, I know I don?t smell bad? I know I brushed my teeth?I did the deodorant!??
She tried offering Smith words of encouragement to help ease his worries.
?You are just nervous. You?re nervous about kissing me. Don?t worry baby, I?ll be gentle,? she remembered telling him.
Ultimately, Smith only felt better about kissing Dawson if his wife was present. But Jada Pinkett would have some words for Smith before his love scene with Dawson
?He wanted Jada to be on set,? Dawson continued. ?And she was letting him know, ?Baby you really need to bring it! Don?t embarrass me.? So, she was on my side on this one.?
Will Smith had trouble with the ?Seven Pounds? love scene because of how he was raised
Smith would later concede that Dawson was telling the truth about their encounter.
?That?s a lie. All right, that?s a little bit true,? Smith said. ?I like being respectful? [The scene was] a lot like being in a bed and she is naked and you don?t want to accidentally? you know.?
In an interview with Collider, he went into a little more detail about his feelings toward the love scene. He chalked up his reaction to making out with Dawson as a result of his upbringing.
?See with the love?like for me, my grandmother was really firm and?my mother and grandmother?about how men are supposed to treat women,? Smith said.
He would also reveal that he would have the other actor?s thoughts in mind while doing these scenes. This would sometimes distract him.
?So it?s like, for me, my worst nightmare is for an actress to come on my set and feel like I?m taking this as an opportunity to get a little quickie feel, you know, some legal cheating going on. I just need, specifically, women to be comfortable around me,? he elaborated. ?I just don?t want to feel like I?m that dude and doing a love scene and her clothes are off and all of that, it just puts me in my defensive space but it also hurts the acting if I?m in that space.?
RELATED: Body Language Expert Explains if Will Smith?s Oscars Slap Was Fake
We wish to thank the writer of this post for this awesome material
[date_timestamp] => 1650084094
)
[9] => Array
(
[title] => 10 Scariest Videos That Went Viral On The Internet
[link] => https://bestmovies.movs.world/scream-away/10-scariest-videos-that-went-viral-on-the-internet/
[dc] => Array
(
[creator] => Harry World
)
[pubdate] => Sat, 16 Apr 2022 04:37:37 +0000
[category] => Scream AwayInternetScariestVideosViral
[guid] => https://bestmovies.movs.world/?p=106860
[description] => With Huggy Wuggy taking the world of TikTok and YouTube horror by storm, there’s no telling if this viral video trend will stay in the annals of horror-based YouTube content. For as long as there has been the internet, there have been stories and videos shared to make the world a little creepier. From quick ... Read more
[content] => Array
(
[encoded] =>
With Huggy Wuggy taking the world of TikTok and YouTube horror by storm, there’s no telling if this viral video trend will stay in the annals of horror-based YouTube content. For as long as there has been the internet, there have been stories and videos shared to make the world a little creepier. From quick seconds long jumpscares to short horror films, they can all be found online.
RELATED: 10 Scary Horror Games From The ’80s (That Are Still Scary Today)
While movies meant to provoke have existed more or less since the dawn of cinema, these disconcerting downloads and malicious .mp4 files are more of a recent occurrence, with many only taking off in popularity after the debut of YouTube in 2005. Either way, they’ll always be around to disturb viewers with plenty of nightmare fuel to make their dreams less than pleasant.
SCREENRANT VIDEO OF THE DAY
I Feel Fantastic
In 2009, YouTube user Creepyblog uploaded an eerie video titled “I Feel Fantastic” that featured a stiff, scary animatronic wearing a wig and women’s clothing singing a high-pitched song that was seemingly generated via a text-to-speech algorithm. Something from the deepest pits of the uncanny valley, those with an irrational fear of mannequins will want to steer clear of this two-and-a-half-minute long video.
After the video’s debut, rumors circulated that it had been put together by a serial killer and that the clothes seen on the mannequin belonged to his victims. However, the creator was later revealed to be John Bergeron, a man with an innocent?albeit creepy?fascination with singing animatronics.
This Is A Special Time
Perhaps one of the most unnerving advertisements of all time, “This Is A Special Time” was a commercial for the Philadelphia-based Little Baby’s Ice Cream and featured a woman standing before the camera covered head-to-toe in what looked like vanilla ice cream. As she scooped some of the desert from the top of her head and ate it, a voiceover extolled the benefits of eating the dairy treat.
RELATED: 10 Scary Movies That Aren’t Horror Films
Obviously, this advertisement was meant to provoke, and the gimmick seems to have worked, as the video has over eighteen million views on YouTube. Unfortunately, Little Baby’s Ice Cream closed in 2019.
Salad Fingers
Salad Fingers is a thirteen-part animated horror web series that originated on the content-sharing site Newgrounds in 2004. Created by David Firth, Salad Fingers follows the titular character, a strange, green-skinned man with elongated fingers, living in what’s implied to be a post-apocalyptic wasteland, passing the time by talking with a series of finger puppets.
With weird premises, nails-on-chalkboard background music, and shocking moments of gore and depravity, Salad Fingers is nothing short of haunting. The series continues to this day, though new installments are incredibly infrequent, and the first installment has over 41 million views on YouTube.
Username 666
Uploaded in 2008, “Username 666” sees a hapless internet user punching www.youtube.com/666 into their browser and refreshing until their taken to a heavily distorted, hellish version of the video-sharing platform. They experience a string of strange tech-related oddities until they attempt to sign out of Windows only to find themselves permanently stuck on the cursed webpage.
RELATED: 10 Best Horror Movies That Aren’t Scary (According To Reddit)
While so out-of-date as to be almost comical, Username 666 is an excellent example of early viral internet horror, and those nostalgic for YouTube’s early days may want to give this one a watch.
Don’t Hug Me I’m Scared
Debuting on YouTube in 2011, Don’t Hug Me I’m Scared is a collection of six short videos intended to come across as a child’s show akin to Seasame Street or The Muppets Show. While each episode beings with standard genre fare, it eventually devolves into a dissonance of disarming and disturbing occurrences.
With over 68 million views, the first episode of Don’t Hug Me I’m Scared is must-see viewing for fans of strange videos. The series was intended to lampoon the sometimes-coercive nature of children’s programming, and an actual television series is supposedly in the works.
The Max Headroom Incident
The Max Headroom Incident is perhaps the most famous television broadcast intrusion of all time. Taking place in November of 1987, an unknown hijacker interrupted 90 seconds of a Doctor Who television broadcast in the Chicago area, interjecting a bizarre video of a man in a Max Headroom mask mumbling and screaming erratically.
While it originally went down as a strange footnote, the incident gained renewed infamy after it went viral on the internet decades after the event took place. Part of the fascination surrounding the incident likely stems from the fact that the hijacker was never caught and that it’s tough to discern what they may have wanted or even what exactly is being said in the video.
Teddy Has An Operation
Uploaded in April 2012, “Teddy Has An Operation” is a strange short film that sees a doctor inspecting the disturbingly-fleshy innards of a teddy bear that has apparently fallen ill. After pulling things like crumpled cigarettes and action figures out of the bear’s organs, he’s sewen back up, supposedly good as new.
“Teddy Has An Operation” isn’t exactly scary, but it is unremittingly weird. It was uploaded by zefrank1, a user otherwise known for their comedy videos. It could be construed as a strange type of surreal comedy, though that’s ultimately for viewers to decide for themselves.
Pokopokoshopping
Created by YouTube user nana825763?the same user who uploaded the “Username 666″ video?”pokopokoshopping” debuted in 2014 and features two cute puppet characters hosting some sort of shopping-themed show. Things fly off the rails pretty quickly as flesh growths begin to appear on walls, products, and the characters themselves, one of the show’s hosts is disemboweled, and spontaneous fires begin to melt the set.
RELATED: 10 Scary Scenes In Otherwise Comedic Movies
While it’s only amassed 2.2 million views in eight years, it’s certainly a YouTube horror gem, as if just about everything on nana825763’s channel.
Dining Room Or There Is Nothing
“Dining Room or There Is Nothing” actually made the rounds across digital forums in the days before the creation of YouTube, but the video attained renewed fame when user David Earle uploaded it to their channel in 2006. It’s a roughly minute-long clip of a mannequin-like girl speaking backward and falling face-first into a bowl before the footage is reversed and she’s revealed to have said “there is nothing.”
This video is utterly terrifying and appears to have been made for no purpose other than to shock. It’s the sort of thing that one desperately tries to forget after viewing.
The Backrooms (Found Footage)
The Backrooms is an internet urban legend that first gained traction in 2019 following a series of eerie posts on popular internet message boards. The mythos surrounds an extra-dimensional series of nearly-endless hallways that traps those unfortunate enough to fall out of reality.
In early 2022, enterprising YouTuber Kane Pixels uploaded a nine-minute short film of a hapless explorer roaming the titular territory, coming across iconic backrooms locations and getting chased by anomalous monsters. The video was the first of a series that establishes original lore surrounding the backrooms concept.
NEXT: Every Shudder Short Ranked By How Scary It Is
Black Widow’s David Harbour Appears In Doctor Strange 2 Commercial
We wish to say thanks to the author of this article for this amazing content
)
[summary] => With Huggy Wuggy taking the world of TikTok and YouTube horror by storm, there’s no telling if this viral video trend will stay in the annals of horror-based YouTube content. For as long as there has been the internet, there have been stories and videos shared to make the world a little creepier. From quick ... Read more
[atom_content] =>
With Huggy Wuggy taking the world of TikTok and YouTube horror by storm, there’s no telling if this viral video trend will stay in the annals of horror-based YouTube content. For as long as there has been the internet, there have been stories and videos shared to make the world a little creepier. From quick seconds long jumpscares to short horror films, they can all be found online.
RELATED: 10 Scary Horror Games From The ’80s (That Are Still Scary Today)
While movies meant to provoke have existed more or less since the dawn of cinema, these disconcerting downloads and malicious .mp4 files are more of a recent occurrence, with many only taking off in popularity after the debut of YouTube in 2005. Either way, they’ll always be around to disturb viewers with plenty of nightmare fuel to make their dreams less than pleasant.
SCREENRANT VIDEO OF THE DAY
I Feel Fantastic
In 2009, YouTube user Creepyblog uploaded an eerie video titled “I Feel Fantastic” that featured a stiff, scary animatronic wearing a wig and women’s clothing singing a high-pitched song that was seemingly generated via a text-to-speech algorithm. Something from the deepest pits of the uncanny valley, those with an irrational fear of mannequins will want to steer clear of this two-and-a-half-minute long video.
After the video’s debut, rumors circulated that it had been put together by a serial killer and that the clothes seen on the mannequin belonged to his victims. However, the creator was later revealed to be John Bergeron, a man with an innocent?albeit creepy?fascination with singing animatronics.
This Is A Special Time
Perhaps one of the most unnerving advertisements of all time, “This Is A Special Time” was a commercial for the Philadelphia-based Little Baby’s Ice Cream and featured a woman standing before the camera covered head-to-toe in what looked like vanilla ice cream. As she scooped some of the desert from the top of her head and ate it, a voiceover extolled the benefits of eating the dairy treat.
RELATED: 10 Scary Movies That Aren’t Horror Films
Obviously, this advertisement was meant to provoke, and the gimmick seems to have worked, as the video has over eighteen million views on YouTube. Unfortunately, Little Baby’s Ice Cream closed in 2019.
Salad Fingers
Salad Fingers is a thirteen-part animated horror web series that originated on the content-sharing site Newgrounds in 2004. Created by David Firth, Salad Fingers follows the titular character, a strange, green-skinned man with elongated fingers, living in what’s implied to be a post-apocalyptic wasteland, passing the time by talking with a series of finger puppets.
With weird premises, nails-on-chalkboard background music, and shocking moments of gore and depravity, Salad Fingers is nothing short of haunting. The series continues to this day, though new installments are incredibly infrequent, and the first installment has over 41 million views on YouTube.
Username 666
Uploaded in 2008, “Username 666” sees a hapless internet user punching www.youtube.com/666 into their browser and refreshing until their taken to a heavily distorted, hellish version of the video-sharing platform. They experience a string of strange tech-related oddities until they attempt to sign out of Windows only to find themselves permanently stuck on the cursed webpage.
RELATED: 10 Best Horror Movies That Aren’t Scary (According To Reddit)
While so out-of-date as to be almost comical, Username 666 is an excellent example of early viral internet horror, and those nostalgic for YouTube’s early days may want to give this one a watch.
Don’t Hug Me I’m Scared
Debuting on YouTube in 2011, Don’t Hug Me I’m Scared is a collection of six short videos intended to come across as a child’s show akin to Seasame Street or The Muppets Show. While each episode beings with standard genre fare, it eventually devolves into a dissonance of disarming and disturbing occurrences.
With over 68 million views, the first episode of Don’t Hug Me I’m Scared is must-see viewing for fans of strange videos. The series was intended to lampoon the sometimes-coercive nature of children’s programming, and an actual television series is supposedly in the works.
The Max Headroom Incident
The Max Headroom Incident is perhaps the most famous television broadcast intrusion of all time. Taking place in November of 1987, an unknown hijacker interrupted 90 seconds of a Doctor Who television broadcast in the Chicago area, interjecting a bizarre video of a man in a Max Headroom mask mumbling and screaming erratically.
While it originally went down as a strange footnote, the incident gained renewed infamy after it went viral on the internet decades after the event took place. Part of the fascination surrounding the incident likely stems from the fact that the hijacker was never caught and that it’s tough to discern what they may have wanted or even what exactly is being said in the video.
Teddy Has An Operation
Uploaded in April 2012, “Teddy Has An Operation” is a strange short film that sees a doctor inspecting the disturbingly-fleshy innards of a teddy bear that has apparently fallen ill. After pulling things like crumpled cigarettes and action figures out of the bear’s organs, he’s sewen back up, supposedly good as new.
“Teddy Has An Operation” isn’t exactly scary, but it is unremittingly weird. It was uploaded by zefrank1, a user otherwise known for their comedy videos. It could be construed as a strange type of surreal comedy, though that’s ultimately for viewers to decide for themselves.
Pokopokoshopping
Created by YouTube user nana825763?the same user who uploaded the “Username 666″ video?”pokopokoshopping” debuted in 2014 and features two cute puppet characters hosting some sort of shopping-themed show. Things fly off the rails pretty quickly as flesh growths begin to appear on walls, products, and the characters themselves, one of the show’s hosts is disemboweled, and spontaneous fires begin to melt the set.
RELATED: 10 Scary Scenes In Otherwise Comedic Movies
While it’s only amassed 2.2 million views in eight years, it’s certainly a YouTube horror gem, as if just about everything on nana825763’s channel.
Dining Room Or There Is Nothing
“Dining Room or There Is Nothing” actually made the rounds across digital forums in the days before the creation of YouTube, but the video attained renewed fame when user David Earle uploaded it to their channel in 2006. It’s a roughly minute-long clip of a mannequin-like girl speaking backward and falling face-first into a bowl before the footage is reversed and she’s revealed to have said “there is nothing.”
This video is utterly terrifying and appears to have been made for no purpose other than to shock. It’s the sort of thing that one desperately tries to forget after viewing.
The Backrooms (Found Footage)
The Backrooms is an internet urban legend that first gained traction in 2019 following a series of eerie posts on popular internet message boards. The mythos surrounds an extra-dimensional series of nearly-endless hallways that traps those unfortunate enough to fall out of reality.
In early 2022, enterprising YouTuber Kane Pixels uploaded a nine-minute short film of a hapless explorer roaming the titular territory, coming across iconic backrooms locations and getting chased by anomalous monsters. The video was the first of a series that establishes original lore surrounding the backrooms concept.
NEXT: Every Shudder Short Ranked By How Scary It Is
Black Widow’s David Harbour Appears In Doctor Strange 2 Commercial
We wish to say thanks to the author of this article for this amazing content
?????? ‘??? ??? ????’-?? ??? ?????? ??????, ?? ??????????? ??? ?????????
Poila Baisakh: ???? ?????? ???? ???? ???????? ???? ???: ?????????? ?????
Devlina Kumar: ?????? ???? ?????-?????? ?????? ??????? ?????!
